Sometimes Similar, Sometimes Dangerously Different: Exploring Resonance, Laminations and Subject-Formation in South India

Infectious Agents and Autophagy: Sometimes You Win, Sometimes You Lose

Sometimes, more is better.

(See the article by El Sahly et al, on pages 703–12.) Influenza causes significant morbidity and mortality with an estimated 36 000 attributable deaths in the United States annually [1]. Human immunodefi-ciency virus (HIV) infection, specifically , advanced disease (CD4 count ,200 cells/lL), has been associated with excess morbidity and mortality [2]. With the use of combination antiretroviral ...

Sometimes size does matter

10.1083/jcb/1722iti3jcb1722iti3Sometimes size does matter D uring myofi broblast differentiation in vitro, “supermature” focal adhesions (FAs) arise due to increased physical stress, report Goffi n et al. (page 259). Additionally, increased tension induces accumulation of αsmooth muscle actin (α-SMA) in stress fi bers that are anchored at these FAs. In vivo, the extracellu...

Sometimes Updates Are Circumscription

Model-based revision of knowledge bases ex­ pressed as first-order theories was shown in [Winslett 88b] to be useful as a means of de­ scribing and reasoning about the effects of ac­ tions. This paper shows that model-based the­ ory revision is actually expressible as a form of circumscription. This shows that in cer­ tain applications, the cumbersome conceptu­ ally machinery of circumscription...

The Ubiquitin Proteasome System in Neurodegenerative Diseases Sometimes the Chicken, Sometimes the Egg

The ubiquitin-proteasome system targets numerous cellular proteins for degradation. In addition, modifications by ubiquitin-like proteins as well as proteins containing ubiquitin-interacting and -associated motifs modulate many others. This tightly controlled process involves multiple specific and general enzymes of the system as well as many modifying and ancillary proteins. Thus, it is not su...